![]() The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. ĪBL proto-oncogene 1, non-receptor tyrosine kinase|This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. Its kinase activity is stimulated by clathrin. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. 43:D512-20.ģ59 sets of substrates of kinases from the curated PhosphoSitePlus Substrates of Kinases dataset.ĪP2 associated kinase 1|Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. (2015) PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. (2004) PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation. Substrate-kinase associations from low-throughput or high-throughput phosphoproteomics data Kinase-substrate interactions curated from low-throughput or high-throughput phosphoproteomics studies PhosphoSitePlus Substrates of Kinases Dataset Description ![]()
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